Updates
RECORD NOTES · UNSCHEDULEDWe publish when the record moves: a trial readout, an approval, a correction. No filler.
2026-10-10 · NO. 004 · PURCHASING PATH
The purchasing window: fourteen countries can now try to buy twice-yearly lenacapavir
Fourteen countries can buy twice-yearly lenacapavir for PrEP through PAHO's revolving funds. A purchasing path, not a new license and not a new approval.
2026-09-17 · NO. 003 · CONFERENCE READOUT
The decoy problem: three ways AIDS 2026 tried to out-design immunodominance
Delete the V1 loop, retrain gp41 antibodies, or shortcut to rare precursors with CH505 mRNA. Monkeys first, CLEAR in humans in 2027.
2026-09-04 · NO. 002 · RECORD UPDATE
The record moves: first shots in Africa, first safety readout in people with HIV
BRILLIANT 011 opens in Cape Town after the funding cuts; RENEW-SHCS reports germline-targeting safety in people on ART.
2026-09-01 · NO. 001 · LAUNCH
Why we opened the ledger: launch notes
What this site is, what it refuses to be, and how every number on it is sourced.